Skeletal Muscle Following Intense Endurance Exercise

Protein-leucine Ingestion Activates a Regenerative Inflammo-Myogenic Transcriptome in 1 Skeletal Muscle Following Intense Endurance Exercise 2 3 David S. Rowlands, Andre R. Nelson, Frederic Raymond, Sylviane Metairon, Robert 4 Mansourian, Jim Clarke, Trent Stellingwerff, Stuart M. Phillips 5 6 School of Sport and Exercise and Institute of Food Nutrition, and Human Health, Massey University, 7 Wellington, New Zealand 8 Institute of Sport, Exercise and Active Living, Victoria University, Melbourne, Australia 9 Nestle Research Centre and Nestlé Institute of Health Sciences, Lausanne, Switzerland 10 Canadian Sport Institute Pacific, Victoria, Canada 11 6 McMaster University, Department of Kinesiology, Hamilton, Canada 12 13 Running head: Protein-leucine fed skeletal muscle transcriptome 14 15 Address for reprint requests and other correspondence: 16 D. S. Rowlands, 17 School of Sport and Exercise, Massey Univ., 63 Wallace St., Mt. Cook, 18 Wellington 6011, New Zealand (e-mail: [email protected]). 19 20 Data Supplements: 21 S1. Microarray geneset selection for two time points and three treatment contrasts. 22 S2. Ingenuity Pathway Analysis: functional category analysis results, by gene and category. Gene 23 abbreviations. 24 S3. Ingenuity Pathway Analysis: functional category analysis. 25 S4. Top-ranked gene network molecular functions. 26 S5. Amino acid-gene correlations, heat maps, and bioinformatics at 30 min post exercise. 27 S6. Amino acid-gene correlations, heat maps, and bioinformatics at 240 min post exercise. 28 Articles in PresS. Physiol Genomics (October 27, 2015). doi:10.1152/physiolgenomics.00068.2015